Lee Hyeong-Woo, Moon Sung-Ung, Kim Yeon-Joo, Cho Shin-Hyeong, Lin Khin, Na Byoung-Kuk, Kim Tong-Soo
Division of Malaria and Parasitic Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul 122-701, Korea.
Korean J Parasitol. 2008 Sep;46(3):195-8. doi: 10.3347/kjp.2008.46.3.195.
Plasmodium falciparum liver stage antigen-1 (PfLSA-1) is one of the few antigens expressed exclusively in liver stage parasites. In this study, we evaluated the antibody responses against recombinant PfLSA-1 in naturally infected individuals in Myanmar. High levels of antibody responses (70.7%) were detected in 82 serum samples from 116 infected individuals, and IgG responses to PfLSA-1 principally composed of responses of IgG1 and IgG3 subclasses. These results show that PfLSA-1 elicits effective antibody responses in individuals infected with P. falciparum, and thus it could be not only an attractive candidate protein for vaccine development, but also a useful antigen for serodiagnosis of the infection.
恶性疟原虫肝期抗原-1（PfLSA-1）是仅在肝期疟原虫中表达的少数抗原之一。在本研究中，我们评估了缅甸自然感染个体对重组PfLSA-1的抗体反应。在116名感染个体的82份血清样本中检测到高水平的抗体反应（70.7%），并且对PfLSA-1的IgG反应主要由IgG1和IgG3亚类的反应组成。这些结果表明，PfLSA-1在恶性疟原虫感染个体中引发有效的抗体反应，因此它不仅可能是疫苗开发中一个有吸引力的候选蛋白，而且是该感染血清学诊断的有用抗原。
