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间日疟原虫热休克蛋白70的特性及其对三日疟血清学诊断价值的评估。

Characterization of Plasmodium vivax heat shock protein 70 and evaluation of its value for serodiagnosis of tertian malaria.

作者信息

Na Byoung-Kuk, Park Jae-Won, Lee Hyeong-Woo, Lin Klin, Kim Seon-Hee, Bae Young-An, Sohn Woon-Mok, Kim Tong-Soo, Kong Yoon

机构信息

Department of Molecular Parasitology, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea.

出版信息

Clin Vaccine Immunol. 2007 Mar;14(3):320-2. doi: 10.1128/CVI.00424-06. Epub 2007 Jan 17.

DOI:10.1128/CVI.00424-06
PMID:17229883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1828846/
Abstract

We have characterized Plasmodium vivax heat shock protein 70 (PvHSP70) and evaluated serodiagnostic applicability of recombinant PvHSP70 (rPvHSP70). In enzyme-linked immunosorbent assays and immunoblot analyses, rPvHSP70 showed high sensitivity (88.8%; 203/228 cases). P. falciparum-infected sera revealed positive reactions (78.8%). The predominant immunoglobulin G (IgG) subclasses were segregated with IgG1 and IgG3.

摘要

我们已对间日疟原虫热休克蛋白70（PvHSP70）进行了特性分析，并评估了重组PvHSP70（rPvHSP70）的血清学诊断适用性。在酶联免疫吸附测定和免疫印迹分析中，rPvHSP70显示出高灵敏度（88.8%；203/228例）。感染恶性疟原虫的血清呈现阳性反应（78.8%）。主要的免疫球蛋白G（IgG）亚类与IgG1和IgG3分离。

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本文引用的文献

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Parasitol Res. 2005 Jul;96(5):321-5. doi: 10.1007/s00436-005-1364-0. Epub 2005 May 28.
2
Hsp70 chaperones: cellular functions and molecular mechanism.热休克蛋白70伴侣蛋白：细胞功能与分子机制
Cell Mol Life Sci. 2005 Mar;62(6):670-84. doi: 10.1007/s00018-004-4464-6.
3
Recurrent fever promotes Plasmodium falciparum development in human erythrocytes.复发性发热促进恶性疟原虫在人体红细胞中的发育。
J Biol Chem. 2004 Nov 5;279(45):46692-9. doi: 10.1074/jbc.M409165200. Epub 2004 Aug 31.
4
Overproduction, purification, and characterization of the Plasmodium falciparum heat shock protein 70.恶性疟原虫热休克蛋白70的过量生产、纯化及特性分析
Protein Expr Purif. 2004 Feb;33(2):214-22. doi: 10.1016/j.pep.2003.09.010.
5
The IgG-subclass distribution of naturally acquired antibodies to Plasmodium falciparum, in relation to malaria exposure and severity.恶性疟原虫自然获得性抗体的IgG亚类分布与疟疾暴露及严重程度的关系。
Ann Trop Med Parasitol. 1998 Apr;92(3):245-56. doi: 10.1080/00034989859807.
6
Evidence for epitope-specific thymus-independent response against a repeat sequence in a protein antigen.针对蛋白质抗原中重复序列的表位特异性非胸腺依赖性应答的证据。
Immunology. 1998 May;94(1):28-34. doi: 10.1046/j.1365-2567.1998.00486.x.
7
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8
Threonine 204 of the chaperone protein Hsc70 influences the structure of the active site, but is not essential for ATP hydrolysis.
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9
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