精神分裂症、分裂情感性障碍和分裂型人格障碍中脑电活动与调制听觉音调的同步性
EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorder.
作者信息
Brenner Colleen A, Sporns Olaf, Lysaker Paul H, O'Donnell Brian F
机构信息
Department of Psychology, Indiana University, 1101 East Tenth St., Bloomington, IN 47405, USA.
出版信息
Am J Psychiatry. 2003 Dec;160(12):2238-40. doi: 10.1176/appi.ajp.160.12.2238.
OBJECTIVE
The authors tested whether neural synchronization deficits were present in subjects with schizophrenia and schizotypal personality disorder.
METHOD
Amplitude-modulated tones were used to evaluate auditory steady-state evoked potential entrainment in a combined group of 21 subjects with schizophrenia or schizoaffective disorder, 11 subjects with schizotypal personality disorder, and 22 nonpsychiatric comparison subjects.
RESULTS
The schizophrenia or schizoaffective disorder group exhibited decreased power compared to the schizotypal personality disorder and nonpsychiatric comparison groups. There were no differences between groups in N100 amplitude.
CONCLUSIONS
Subjects with schizophrenia but not subjects with schizotypal personality disorder have deficits in steady-state responses to periodic stimuli, despite an intact response to sensory-evoked potentials (N100). These deficits reflect aberrant neural synchronization or resolution and may contribute to disturbed perceptual and cognitive integration in schizophrenia.
目的
作者测试了精神分裂症和分裂型人格障碍患者是否存在神经同步缺陷。
方法
使用调幅音来评估21名精神分裂症或分裂情感性障碍患者、11名分裂型人格障碍患者和22名非精神科对照受试者组成的联合组中的听觉稳态诱发电位夹带情况。
结果
与分裂型人格障碍组和非精神科对照组相比，精神分裂症或分裂情感性障碍组的功率降低。各组之间N100波幅无差异。
结论
精神分裂症患者而非分裂型人格障碍患者对周期性刺激的稳态反应存在缺陷，尽管对感觉诱发电位（N100）的反应完好。这些缺陷反映了异常的神经同步或分辨能力，可能导致精神分裂症患者的感知和认知整合受到干扰。
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