Bergmann J F, Caulin C, Genève J, Simoneau G, Segrestaa J M
Clinique thérapeutique, Hôpital Lariboisière, Paris.
Agressologie. 1991;32(2):127-9.
This study investigated the effect of three different mental stress tests on gastric transmucosal electric potential difference (GPD). GPD measurement was carried out in six healthy volunteers using the agar-KCl bridges method during dichotomous listening, the ringing of a telephone and 90 dB noise. Cardiac, pulmonary and psychological responses to stress were evaluated at the same time. During the stress period, two of the subjects had no change in GPD as well as no extragastric modification due to the stressor. The four other volunteers had a significant stress-induced fall in GPD (12.5 + 5.6 mV) with a simultaneous acceleration of heart and respiration rates and an increase in systolic blood pressure and anxiety feelings which were evaluated on a visual scale. Such mental stress, possibly mediated by autonomous nervous system, may cause some gastric mucosa changes inducing the retrodiffusion of H+ ions and a fall in GPD. This model could be useful in therapeutic research into the prevention and treatment of stress-induced gastric lesions.
本研究调查了三种不同心理应激测试对胃黏膜跨膜电位差（GPD）的影响。在六名健康志愿者中，采用琼脂 - 氯化钾桥法，在二分听、电话铃声和90分贝噪音期间测量GPD。同时评估应激对心脏、肺部和心理的反应。在应激期间，两名受试者的GPD没有变化，也没有因应激源引起的胃外改变。另外四名志愿者的GPD因应激而显著下降（12.5 + 5.6毫伏），同时心率和呼吸频率加快，收缩压升高，焦虑感增强，焦虑感通过视觉量表进行评估。这种心理应激可能由自主神经系统介导，可能会导致一些胃黏膜变化，引起氢离子逆向扩散和GPD下降。该模型可能有助于应激性胃损伤预防和治疗的治疗研究。
