Sorrel Jonathan E, Bishop Charles E, Spankovich Christopher, Su Dan, Valle Karen, Seals Samantha, Schweinfurth John M
Department of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, Mississippi, U.S.A.
Department of Data Science, University of Mississippi Medical Center, Jackson, Mississippi, U.S.A.
Laryngoscope. 2018 Jun;128(6):1438-1444. doi: 10.1002/lary.26896. Epub 2017 Oct 9.
OBJECTIVES/HYPOTHESIS: To evaluate the relationships among measures of stroke risk and hearing in an African American cardiovascular study cohort.
Prospective cohort study.
The relationships between stroke risk profiles and hearing of 1,107 individuals from a cohort of African Americans were assessed. Several different hearing pure-tone averages (PTAs) were constructed representing different frequency regions of hearing, namely PTA low, PTA mid, and PTA high. Stroke risk profiles were calculated using validated 10-year cardiovascular disease risk scores. Gamma regression analyses were performed for each PTA given as a continuous variable with change in stroke risk score. Logistic regression analyses, presented as odds ratios, were performed with hearing loss defined as any PTA >25 dB hearing level. Stratification models were analyzed for age quarterlies and among sex.
Single unit increases of stroke risk percentage were found to be predictive of increases in all PTA threshold levels in gamma regression analyses for the overall pooled sample. The relationship was influenced by age, where fewer significant relationships were observed at higher ages. When analyzed with respect to stroke risk categories, using low risk as the reference group, there was found to be a significant association between stroke risk and hearing loss in the medium- and high-risk groups, with a stronger relationship in the high-risk group for all PTA threshold levels.
This study provides evidence that stroke risk has a positive predictive relationship with hearing pure-tone threshold.
2b. Laryngoscope, 128:1438-1444, 2018.
目的/假设：在一项非裔美国人心血管研究队列中评估中风风险指标与听力之间的关系。
前瞻性队列研究。
评估了来自非裔美国人队列的1107名个体的中风风险概况与听力之间的关系。构建了几个不同的听力纯音平均听阈（PTA），分别代表听力的不同频率区域，即低PTA、中PTA和高PTA。使用经过验证的10年心血管疾病风险评分计算中风风险概况。对每个作为连续变量的PTA与中风风险评分的变化进行伽马回归分析。以比值比表示的逻辑回归分析，将听力损失定义为任何PTA>25 dB听力水平。对年龄四分位数和性别进行分层模型分析。
在总体合并样本的伽马回归分析中，发现中风风险百分比的单单位增加可预测所有PTA阈值水平的增加。这种关系受年龄影响，在较高年龄时观察到的显著关系较少。当按中风风险类别分析时，以低风险组为参照组，发现中风险组和高风险组的中风风险与听力损失之间存在显著关联，在所有PTA阈值水平上，高风险组的关系更强。
本研究提供了证据表明中风风险与听力纯音阈值呈正预测关系。
2b。《喉镜》，2018年，第128卷，第1438 - 1444页。
