Prais Botelho Adriana, Santos-Zago Lilia Ferreira, Costa de Oliveira Admar
Laboratory of Lipids, Department of Food and Nutrition, College of Food Engineering, State University of Campinas, Brasil.
Arch Latinoam Nutr. 2008 Jun;58(2):156-63.
Dietary supplementation with conjugated linoleic acid (CLA) may reduce body fat mass and increase lean body mass in various species. The objective of this study was to study the effects of conjugated linoleic acid (CLA) supplementation on body composition, serum leptin and triacylglycerol levels in Wistar rats. Rats received linoleic acid (group C) or conjugated linoleic acid (group AE, supplemented with AdvantEdge CLA, and group CO, supplemented with CLA One) in the concentrations of 2% of daily feed consumption. Serum leptin and triacylglycerol levels of rats were measured by means of commercial kits. After 42 days of supplementation, rats in the control group exhibited body fat contents of 53.94 +/- 6.80 g, and those in groups AE and CO had 45.43 +/- 4.86 g and 43.75 +/- 1.93 g, respectively, corresponding to a mean body fat reduction of 18%. Water, whole body protein and ash contents of rats supplemented with CLA were statistically higher relative to control group content (corresponding to a mean increasing of 7.65%; 6.5% and 12.35%, respectively). Experimental groups AE and CO, which received CLA supplementation, had statistically lower serum leptin levels (3.45 +/- 0.46 ng/mL and 3.08 +/- 0.19 ng/mL, respectively) relative to the control group (4.21 +/- 0.22 ng/mL) which received linoleic acid. Triacylglycerol levels did not change after CLA supplementation (p > 0.05). Supplementation with conjugated linoleic acid in the concentration of 2% of mean daily feed consumption was able to change body composition of rats after 42 days of experimentation.
补充共轭亚油酸（CLA）的饮食可能会减少多种物种的体脂量并增加瘦体重。本研究的目的是研究补充共轭亚油酸（CLA）对Wistar大鼠身体成分、血清瘦素和甘油三酯水平的影响。大鼠以每日饲料消耗量的2%的浓度摄入亚油酸（C组）或共轭亚油酸（AE组，补充AdvantEdge CLA；CO组，补充CLA One）。通过商业试剂盒测量大鼠的血清瘦素和甘油三酯水平。补充42天后，对照组大鼠的体脂含量为53.94±6.80克，AE组和CO组大鼠的体脂含量分别为45.43±4.86克和43.75±1.93克，平均体脂减少了18%。补充CLA的大鼠的水、全身蛋白质和灰分含量相对于对照组含量在统计学上更高（分别对应平均增加7.65%、6.5%和12.35%）。接受CLA补充的实验组AE和CO的血清瘦素水平相对于接受亚油酸的对照组（4.21±0.22纳克/毫升）在统计学上更低（分别为3.45±0.46纳克/毫升和3.08±0.19纳克/毫升）。补充CLA后甘油三酯水平没有变化（p>0.05）。在实验42天后，以平均每日饲料消耗量的2%的浓度补充共轭亚油酸能够改变大鼠的身体成分。
