Vesper Hubert W, Botelho Julianne C, Shacklady Christopher, Smith Antoinette, Myers Gary L
Centers for Disease Control and Prevention, Division of Laboratory Sciences, 4770 Buford Hwy NE MS F25, Atlanta, GA 30341, United States.
Steroids. 2008 Dec 12;73(13):1286-92. doi: 10.1016/j.steroids.2008.09.008. Epub 2008 Sep 26.
Estradiol and testosterone measurements are widely used to assess steroid hormone status and to monitor stimulative, suppressive, or replacement therapy among children and adults of both sexes. Despite their common application, these measurements - particularly at low concentrations - show only limited comparability among assays, such as those observed for testosterone among women or for estradiol among postmenopausal women. This shortcoming hampers progress in research and in research translation. To overcome this, the Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences (CDC/NCEH/DLS) initiated a project to standardize and to improve steroid hormone measurements. The project is a collaborative effort between institutions, organizations, and groups involved in estradiol and testosterone testing, test interpretation, and use. Specific activities are scheduled based on needs assessments conducted with the clinical, research, and public health communities. The initial focus of this standardization project is to improve analytical measurements through reference laboratory activities. As part of the project's translational activities, CDC/NCEH/DLS will work further with professional societies and organizations to improve pre- and postanalytical issues that affect results from these measurements and their interpretation.
雌二醇和睾酮检测被广泛用于评估类固醇激素状态，并监测两性儿童和成人的刺激、抑制或替代疗法。尽管它们应用广泛，但这些检测——尤其是在低浓度时——在不同检测方法之间的可比性有限，比如在女性睾酮检测或绝经后女性雌二醇检测中所观察到的情况。这一缺点阻碍了研究及研究成果转化的进展。为克服这一问题，美国疾病控制与预防中心国家环境卫生中心实验室科学部（CDC/NCEH/DLS）启动了一个项目，以规范和改进类固醇激素检测。该项目是参与雌二醇和睾酮检测、检测结果解读及应用的各机构、组织和团体之间的合作。具体活动根据对临床、研究和公共卫生领域进行的需求评估来安排。这个标准化项目的初始重点是通过参考实验室活动来改进分析检测。作为该项目转化活动的一部分，CDC/NCEH/DLS将进一步与专业协会和组织合作，以改进影响这些检测结果及其解读的分析前和分析后问题。
