Herpel E, Koleganova N, Schirmacher P
Pathologisches Institut, Universitätsklinikum, Heidelberg.
Pathologe. 2008 Nov;29 Suppl 2:204-9. doi: 10.1007/s00292-008-1067-2.
The tissue bank of the National Centre for Tumour Diseases (NCT) in Heidelberg, Germany, was founded in 2005 by the University Hospital of Heidelberg and the German Cancer Research Centre as a section of the NCT. It is a nonprofit organization with a completely evaluated legal and ethical framework and supports the Comprehensive Cancer Centre concept. Its main aim is the acquisition and characterization of fresh-frozen and paraffin-embedded human tissues according to the standards of good scientific practice and the promotion of interdisciplinary tumour research of the comprehensive cancer centre and its cooperating partners. It also offers expert project assistance: a project leader can submit a short proposal, and the tissue collecting/preparing process will be performed in cooperation with a specialised pathologist and, if applicable, an experienced clinical researcher. The tissue bank is also a central platform for further developing of innovative technologies for tissue handling, e.g. multi-tissue-array and virtual microscopy, with links to digital image analysis and bioinformatics. Thus, the NCT tissue bank represents a model for innovative biobanking and for institutions with active interdisciplinary cancer research.
德国海德堡国家肿瘤疾病中心(NCT)的组织库于2005年由海德堡大学医院和德国癌症研究中心作为NCT的一个部门共同建立。它是一个具有完全评估的法律和伦理框架的非营利组织,支持综合癌症中心的理念。其主要目标是按照良好科学实践的标准获取和鉴定新鲜冷冻及石蜡包埋的人体组织,并促进综合癌症中心及其合作伙伴的跨学科肿瘤研究。它还提供专家项目协助:项目负责人可以提交简短的提案,组织采集/制备过程将与专业病理学家合作进行,如有需要,还会与经验丰富的临床研究人员合作。该组织库也是进一步开发组织处理创新技术(如多组织阵列和虚拟显微镜)的核心平台,与数字图像分析和生物信息学相联系。因此,NCT组织库代表了创新生物样本库以及积极开展跨学科癌症研究的机构的典范。