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Identification, expression, characterization, and immunolocalization of lactate dehydrogenase from Taenia asiatica.

作者信息

Huang Jiang, Huang Yan, Wu Xuan, Du Wuying, Yu Xinbing, Hu Xuchu

机构信息

Department of Parasitology, Guiyang Medical College, Guiyang, China.

出版信息

Parasitol Res. 2009 Jan;104(2):287-93. doi: 10.1007/s00436-008-1190-2. Epub 2008 Oct 4.

DOI:10.1007/s00436-008-1190-2
PMID:18836746
Abstract

From the expression sequence tags (ESTs) of Taenia asiatica, an EST containing a putative open reading frame of 993 bp was identified as lactate dehydrogenase (TaLDH) homologue. Recombinant TaLDH (rTaLDH) was expressed in Escherichia coli BL21/DE3 and purified. rTaLDH had a specific LDH activity and could be recognized in serum from swine or patient infected with T. asiatica. TaLDH was immunolocalized on the tegument of T. asiatica adult and embryonic membrane of oncosphere. Our study suggested that TaLDH is a potential drug target and candidate antigen for immunodiagnosis and vaccine for taeniasis and viscero-cysticercosis caused by T. asiatica.

摘要

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鉴定小分子酶抑制剂作为广谱驱虫药。
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