一种从醛类化合物简单一锅法制备重氮乙酰乙酸酯衍生物的方法。
A simple one-pot preparation of diazoacetoacetate derivatives from aldehydes.
作者信息
Erhunmwunse Marvis O, Steel Patrick G
机构信息
Department of Chemistry, University of Durham, Science Laboratories, South Road, Durham DH1 3LE, UK.
出版信息
J Org Chem. 2008 Nov 7;73(21):8675-7. doi: 10.1021/jo8017523. Epub 2008 Oct 8.
PMID:18839995
Abstract
Diazoacetoacetate derivatives can be simply and efficiently prepared from aldehydes in a one-pot process involving initial DBU-promoted "aldol" condensation with ethyl diazoacetate followed by in situ oxidation with IBX. Aryl, alkyl, and unsaturated aldehydes are all viable substrates.
摘要
重氮乙酰乙酸酯衍生物可以通过醛类以一锅法简单高效地制备，该过程包括首先由DBU促进与重氮乙酸乙酯进行“羟醛”缩合，然后用IBX进行原位氧化。芳基、烷基和不饱和醛都是可行的底物。
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