van der Tol Arjan, Hussain Asrar, Sever Memhet Sukru, Claus Stefaan, Van Biesen Wim, Hoste Eric, Khan Samuel, Vanholder Raymond
Department of internal Medicine, Renal Division, University Hospital, Ghent, Belgium.
Nephrol Dial Transplant. 2009 Mar;24(3):907-12. doi: 10.1093/ndt/gfn557. Epub 2008 Oct 8.
In the aftermath of earthquakes, the cumulative incidence of crush-induced acute kidney injury (AKI) is difficult to predict. Insight into factors determining this risk is indispensable to allow adequate logistical planning, which is a prerogative for success in disaster management.
Data of 88 crush-related AKI patients in the aftermath of the Kashmir earthquake were collected and outcome measures were analysed. Then the findings were compared with the data of 596 crush-related AKI patients of the Marmara earthquake.
The earthquake in Kashmir occurred in a rural area with lack of medical facilities and difficult transportation conditions while the earthquake in Marmara occurred in an urban area with more efficient transport possibilities. In Kashmir we reported fewer patients with treated AKI (1.2 AKI per 1000 deaths, 1.3 AKI per 1000 victims) than in Marmara (34.1 AKI per 1000 deaths; P < 0.001, 13.6 AKI per 1000 victims; P < 0.001). Time lag between earthquake and admission to hospitals was longer in Kashmir (5.8 +/- 5.8 days) than in Marmara (3.5 +/- 3.7 days; P < 0.001). The frequencies of fasciotomies (P < 0.001), amputations (P < 0.001) and dialysis (P = 0.005) were lower in Kashmir, than in Marmara AKI patients.
The cumulative incidence of treated AKI related to number of deaths or victims might differ substantially among earthquakes. Many factors may affect the frequency of AKI: hampered rescue and transport possibilities; destroyed medical facilities on the spot; availability or not of sophisticated therapeutic possibilities and structure of the buildings might all have impacted on different cumulative incidence between Kashmir and Marmara.
地震过后,挤压所致急性肾损伤(AKI)的累积发病率难以预测。深入了解决定该风险的因素对于进行充分的后勤规划必不可少,而后勤规划是灾害管理取得成功的一项先决条件。
收集了克什米尔地震后88例与挤压相关的AKI患者的数据,并对结果指标进行了分析。然后将这些结果与马尔马拉地震中596例与挤压相关的AKI患者的数据进行比较。
克什米尔地震发生在一个农村地区,医疗设施匮乏且交通条件困难,而马尔马拉地震发生在一个交通更便利的城市地区。我们发现,克什米尔接受治疗的AKI患者数量(每1000例死亡中有1.2例AKI,每1000名受害者中有1.3例AKI)少于马尔马拉(每1000例死亡中有34.1例AKI;P<0.001,每1000名受害者中有13.6例AKI;P<0.001)。克什米尔地震到入院的时间间隔(5.8±5.8天)比马尔马拉(3.5±3.7天;P<0.001)更长。克什米尔AKI患者的筋膜切开术(P<0.001)、截肢术(P<0.001)和透析(P=0.005)频率低于马尔马拉AKI患者。
与死亡人数或受害者数量相关的接受治疗的AKI累积发病率在不同地震之间可能有很大差异。许多因素可能影响AKI的发生频率:救援和运输受阻;现场医疗设施被毁;是否具备先进的治疗手段以及建筑物结构等,所有这些都可能影响克什米尔和马尔马拉之间不同的累积发病率。