de Castro S M M, van Eijck C H J, Rutten J P, Dejong C H, van Goor H, Busch O R C, Gouma D J
Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands.
Br J Surg. 2008 Nov;95(11):1380-6. doi: 10.1002/bjs.6308.
Pancreas-preserving total duodenectomy (PPTD) was introduced as a replacement for pancreatoduodenectomy (PD) for familial adenomatous polyposis (FAP). This study analysed the results of PPTD in the Netherlands and reviewed the relevant literature.
All 26 patients who underwent PPTD for FAP in four centres in the Netherlands between January 2000 and January 2007 were compared with a group of 77 patients who had PD for ampulla of Vater adenocarcinoma at one centre during the same interval.
Morbidity rates were similar after PPTD for FAP (16 patients, 62 per cent) and PD for ampulla of Vater adenocarcinoma (44 patients, 57 per cent) (P = 0.694). One patient (4 per cent) died after PPTD and two (3 per cent) after PD. A review of the literature, including patients from the present study, found that 71 patients had PPTD, with postoperative morbidity in 36 (51 per cent) and one death (1 per cent). In publications containing a total of 94 patients who underwent PD for FAP, 43 (46 per cent) developed complications and three (3 per cent) died.
PPTD has similar short-term results to PD in terms of morbidity and mortality.
保留胰腺的全十二指肠切除术（PPTD）被引入用于替代家族性腺瘤性息肉病（FAP）的胰十二指肠切除术（PD）。本研究分析了荷兰PPTD的结果并回顾了相关文献。
将2000年1月至2007年1月期间在荷兰四个中心接受FAP的PPTD的所有26例患者与同一时期在一个中心接受Vater壶腹腺癌的PD的77例患者进行比较。
FAP的PPTD（16例患者，62%）和Vater壶腹腺癌的PD（44例患者，57%）后的发病率相似（P = 0.694）。1例患者（4%）在PPTD后死亡，2例（3%）在PD后死亡。对包括本研究患者在内的文献进行回顾发现，71例患者接受了PPTD，其中36例（51%）有术后发病，1例（1%）死亡。在包含总共94例接受FAP的PD的患者的出版物中，43例（46%）出现并发症，3例（3%）死亡。
PPTD在发病率和死亡率方面与PD有相似的短期结果。
