顽固性动脉高血压与补体C3和C反应蛋白的较高血液水平相关。
Resistant arterial hypertension is associated with higher blood levels of complement C3 and C-reactive protein.
作者信息
Magen Eli, Mishal Joseph, Paskin Jana, Glick Zahava, Yosefy Chaim, Kidon Mona, Schlesinger Menachem
机构信息
Medicine B Department, Barzilai Medical Center, Barzilai Hospital, Ben Gurion University of Negev, Ashkelon, Israel.
出版信息
J Clin Hypertens (Greenwich). 2008 Sep;10(9):677-83. doi: 10.1111/j.1751-7176.2008.00002.x.
Abstract
Arterial hypertension is associated with increased plasma levels of complement C3, C4, and C-reactive protein (CRP). The aim of the study was to compare these laboratory markers in patients with resistant arterial hypertension (RAH) and controlled arterial hypertension (CAH). Patients with RAH (n = 34), those with CAH (n = 34), and 26 normotensive controls were included. White blood cell count, erythrocyte sedimentation rates, and blood levels of complement components C3, C4, and high-sensitivity C-reactive protein (hs-CRP) were compared among the study groups. In the RAH group, serum C3 (183.9+/-47.5 mg/dL) and hs-CRP (6.9+/-5.8 mg/L) were higher than in the CAH group (C3, 123.1+/-42.3 mg/dL; P < .001, hs-CRP, 4.2+/-4.8; P = .021, respectively). Significant positive correlations between systolic blood pressure and C3 (r = 0.6481; P < .001) and hs-CRP (r = 0.3968; P = .02) were observed in the RAH group. RAH is associated with higher blood levels of C3 and CRP.
摘要
动脉高血压与血浆补体C3、C4和C反应蛋白（CRP）水平升高有关。本研究的目的是比较难治性动脉高血压（RAH）患者和血压控制良好的动脉高血压（CAH）患者的这些实验室指标。纳入了34例RAH患者、34例CAH患者和26例血压正常的对照者。比较了研究组之间的白细胞计数、红细胞沉降率以及补体成分C3、C4和高敏C反应蛋白（hs-CRP）的血水平。在RAH组中，血清C3（183.9±47.5mg/dL）和hs-CRP（6.9±5.8mg/L）高于CAH组（C3，123.1±42.3mg/dL；P<.001，hs-CRP，4.2±4.8；P=.021）。在RAH组中，观察到收缩压与C3（r=0.6481；P<.001）和hs-CRP（r=0.3968；P=.02）之间存在显著正相关。RAH与较高的C3和CRP血水平相关。
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