白细胞介素-6对CD4 T细胞反应的影响。
The effects of IL-6 on CD4 T cell responses.
作者信息
Dienz Oliver, Rincon Mercedes
机构信息
Department of Medicine/Immunobiology program, Given Medical Building D305, University of Vermont, 89 Beaumont Avenue, Burlington, VT 05405, USA.
出版信息
Clin Immunol. 2009 Jan;130(1):27-33. doi: 10.1016/j.clim.2008.08.018. Epub 2008 Oct 8.
Abstract
Cytokines have long been known to profoundly influence the adaptive immune response by determining CD4 T cell differentiation. Although IL-6 has been initially characterized as a B cell growth factor and inducer of antibody production research from our lab and others has revealed over the last years that IL-6 also plays a significant role in CD4 T cell differentiation. This review highlights the variety of ways in which IL-6 affects CD4 effector functions and how this may contribute to different types of diseases.
摘要
长期以来，人们一直认为细胞因子通过决定CD4 T细胞分化来深刻影响适应性免疫反应。尽管白细胞介素-6（IL-6）最初被认为是一种B细胞生长因子和抗体产生的诱导剂，但近年来我们实验室和其他机构的研究表明，IL-6在CD4 T细胞分化中也起着重要作用。这篇综述重点介绍了IL-6影响CD4效应功能的多种方式，以及这可能如何导致不同类型的疾病。
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