Hao Gao, Qing-Hua Zhang, Miao-Miao Jiang, Jin-Shan Tang, Cheng-Du Miao, Kui Hong, Michio Namikoshi, Nai-Li Wang, Xin-Sheng Yao
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
Magn Reson Chem. 2008 Dec;46(12):1148-52. doi: 10.1002/mrc.2338.
A series of polyketide-originated metabolites (1-5) were isolated from a marine sponge-derived fungus Mycelia sterilia. Of these, 1-3 were new compounds. Their structures were elucidated by spectroscopic methods as (4R*, 5S*, 6S*, 8S*, 13R*)-1-(2,8-dihydroxy-1,2,6-trimethyl-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl)-3-methoxy-propan-1-one (1), 4,8-dihydroxy-7-(2-hydroxy-ethyl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one (2) and 1-methyl-naphthalene-2,6-dicarboxylic acid (3). In 1, the proton-proton long-range coupling phenomenon claimed attention and was discussed.
从一株来源于海洋海绵的不育丝孢真菌中分离得到了一系列聚酮类代谢产物（1-5）。其中，1-3为新化合物。通过光谱方法确定它们的结构分别为(4R*, 5S*, 6S*, 8S*, 13R*)-1-(2,8-二羟基-1,2,6-三甲基-1,2,6,7,8,8a-六氢萘-1-基)-3-甲氧基-丙-1-酮（1）、4,8-二羟基-7-(2-羟乙基)-6-甲氧基-3,4-二氢-2H-萘-1-酮（2）和1-甲基-萘-2,6-二甲酸（3）。在化合物1中，质子-质子远程偶合现象引起了关注并进行了讨论。
