Salvati P, Whittle B J
Prostaglandins. 1981 Jul;22(1):141-56. doi: 10.1016/0090-6980(81)90061-7.
The vascular actions of several prostanoids and arachidonate lipoxygenase products were investigated on the gastric circulation of rat and rabbit in vitro perfused with Krebs' solution. Under resting conditions, prostacyclin and PGE2 produced small decreases in perfusion pressure with prostacyclin being the more potent. During vasoconstriction induced by infusion of noradrenaline, vasopressin or angiotensin II, prostacyclin was 20-40 times as active as PGE2 as a gastric vasodilator in rat or rabbit stomach. PGF2 alpha was a less potent vasoconstrictor than noradrenaline, while the epoxy-methano endoperoxide analogue produced a long-lasting vasoconstriction. The putative metabolite, 6-oxo-PGE1 was less active than prostacyclin as a vasodilator, having comparable activity to PGE1, whereas 6-oxo-PGF1 alpha had very little activity. The endoperoxide, PGH2 reduced perfusion pressure, this effect being inhibited by concurrent infusion of 15-HPETE. The vasodilation induced by arachidonic acid was likewise reduced by 15-HPETE, and abolished by indomethacin infusion. The arachidonate lipoxygenase hydroperoxides were vasodilator in the gastric circulation, the rank order of potency being 12-HPETE greater than 11-HPETE greater than 5-HPETE greater than 15-HPETE in both rat and rabbit stomach. It is possible that such vasoactive lipoxygenase products, may play modulator roles in the gastric mucosa.
在体外以克雷布斯溶液灌注的大鼠和家兔胃循环中，研究了几种前列腺素和花生四烯酸脂氧合酶产物的血管作用。在静息状态下，前列环素和前列腺素E2使灌注压略有下降，其中前列环素的作用更强。在由去甲肾上腺素、血管加压素或血管紧张素II输注诱导的血管收缩过程中，在大鼠或家兔胃中，前列环素作为胃血管舒张剂的活性是前列腺素E2的20至40倍。前列腺素F2α作为血管收缩剂的效力低于去甲肾上腺素，而环氧甲烯内过氧化物类似物则产生持久的血管收缩。假定的代谢产物6-氧代-前列腺素E1作为血管舒张剂的活性低于前列环素，与前列腺素E1活性相当，而6-氧代-前列腺素F1α的活性则非常低。内过氧化物前列腺素H2降低灌注压，同时输注15-氢过氧二十碳四烯酸可抑制这种作用。花生四烯酸诱导的血管舒张同样被15-氢过氧二十碳四烯酸降低，并被吲哚美辛输注消除。花生四烯酸脂氧合酶氢过氧化物在胃循环中是血管舒张剂，在大鼠和家兔胃中，效力顺序为12-氢过氧二十碳四烯酸＞11-氢过氧二十碳四烯酸＞5-氢过氧二十碳四烯酸＞15-氢过氧二十碳四烯酸。这类血管活性脂氧合酶产物可能在胃黏膜中起调节作用。
