Lee Jonathan L C
School of Psychology, University of Birmingham, Edgbaston, Birmingham, UK.
Nat Neurosci. 2008 Nov;11(11):1264-6. doi: 10.1038/nn.2205. Epub 2008 Oct 12.
Memories are dynamic, rather than static, in nature. The reactivation of a memory through re-exposure to salient training stimuli results in its destabilization, necessitating a restabilization process known as reconsolidation, a disruption of which leads to amnesia. I found that one normal function of hippocampal memory reconsolidation in rats is to modify the strength of a contextual-fear memory as a result of further learning.
记忆本质上是动态的,而非静态的。通过再次暴露于显著的训练刺激来重新激活记忆会导致其不稳定,这就需要一个称为重新巩固的再稳定过程,对其进行干扰会导致失忆。我发现,大鼠海马体记忆重新巩固的一个正常功能是作为进一步学习的结果来改变情境恐惧记忆的强度。