Department of Biochemistry, BK21 Plus and Research Institute for Veterinary Science, School of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
Int J Mol Sci. 2020 Nov 6;21(21):8337. doi: 10.3390/ijms21218337.
Cholesterol is an essential cell component that functions to create and maintain all kinds of cell membranes and lipoprotein particles. It is crucial to maintain the proper amount of cholesterol at both the cellular and systemic level. Recently, the importance of cholesterol has been reported not only in various cell development processes but also in the development of diseases. Furthermore, the involvement of long non-coding RNAs (lncRNAs), which are regarded as important epigenetic regulators in gene expression, has also been reported in cholesterol homeostasis. It is thus necessary to summarize the research on lncRNAs related to cholesterol with increased interest. This review organized the role of lncRNAs according to the major issues in cholesterol homeostasis: efflux, metabolism and synthesis, and disease process.
胆固醇是一种重要的细胞成分，用于构建和维持各种细胞膜和脂蛋白颗粒。在细胞和全身水平上维持适量的胆固醇至关重要。最近，胆固醇的重要性不仅在各种细胞发育过程中得到了报道，而且在疾病的发展中也得到了报道。此外，长链非编码 RNA（lncRNA）作为基因表达中重要的表观遗传调控因子，也与胆固醇稳态有关。因此，有必要对与胆固醇相关的 lncRNA 研究进行总结。本综述根据胆固醇稳态的主要问题（流出、代谢和合成以及疾病过程）对 lncRNA 的作用进行了组织。
