老年热量限制对大鼠大脑皮质和海马区与年龄相关变化的影响。

Effects of Late-Life Caloric Restriction on Age-Related Alterations in the Rat Cortex and Hippocampus.

机构信息

Department of Science, University Roma Tre, Viale Marconi 446, 00146 Rome, Italy.

Department of Biosciences and Territory, University of Molise, Contrada Fonte Lappone, 86090 Pesche, Italy.

出版信息

Nutrients. 2021 Jan 15;13(1):232. doi: 10.3390/nu13010232.

BACKGROUND

A major problem of aging is the disruption of metabolic homeostasis. This is particularly relevant in the brain where it provokes neurodegeneration. Caloric restriction is a physiologic intervention known to delay the deleterious consequences of aging in several species ranging from yeast to mammals. To date, most studies on experimental models have started this dietary intervention from weaning, which is very difficult to be translated to human beings. Here, we study the effects of a more realistic dietary regimen in rats, starting at an advanced age and lasting for six months.

METHODS

we analyzed in the cortex and hippocampus, the proteins involved in the energetic balance of the cells, cholesterol metabolism, oxidative stress response, inflammation, synaptic impairment, and brain trophism.

RESULTS

our results suggest that caloric restriction in late life can revert only some age-related changes studied here.

背景

衰老的一个主要问题是代谢稳态的破坏。这在大脑中尤为相关，因为它会引发神经退行性变。热量限制是一种生理干预措施，已知可延缓从酵母到哺乳动物等多种物种衰老的有害后果。迄今为止，大多数关于实验模型的研究都从断奶开始进行这种饮食干预，这很难转化为人类。在这里，我们研究了在大鼠中更现实的饮食方案的效果，从老年开始并持续六个月。