Seki K, Nagata I
Department of Obstetrics and Gynecology, National Defense Medical College, Saitama, Japan.
Gynecol Obstet Invest. 1991;31(4):222-5. doi: 10.1159/000293163.
Excursions of plasma glucose and insulin throughout the 24-hour metabolic clock were evaluated in hyperprolactinemic women with pituitary microadenoma. The glucose response to food intake and 24-hour excursion of plasma glucose were not altered in hyperprolactinemic women compared to normal women. Premeal and 24-hour insulin levels were significantly increased in hyperprolactinemic women, though fasting insulin levels were not. Postprandial insulin increments appeared to be more sustained in these patients compared to normal women, though the difference was not statistically significant. And therefore the increased 24-hour concentration of insulin in hyperprolactinemic women appears to be due to the sustained insulin response to meals and increased premeal insulin levels. A slight resistance to insulin was observed in hyperprolactinemic women. That the 24-hour excursion of plasma glucose is not altered in hyperprolactinemic women in the face of decreased sensitivity to insulin may be accounted for by the increased insulin secretion.
对患有垂体微腺瘤的高催乳素血症女性，评估了其在24小时代谢时钟内血浆葡萄糖和胰岛素的波动情况。与正常女性相比，高催乳素血症女性对食物摄入的葡萄糖反应及血浆葡萄糖的24小时波动未发生改变。高催乳素血症女性的餐前和24小时胰岛素水平显著升高，尽管空腹胰岛素水平未升高。与正常女性相比，这些患者餐后胰岛素的增加似乎更持久，尽管差异无统计学意义。因此，高催乳素血症女性24小时胰岛素浓度升高似乎是由于对餐食的胰岛素反应持续以及餐前胰岛素水平升高所致。在高催乳素血症女性中观察到对胰岛素有轻微抵抗。尽管对胰岛素敏感性降低，但高催乳素血症女性血浆葡萄糖的24小时波动未改变，这可能是由于胰岛素分泌增加所致。
