Johansson E, Pyrhönen S, Rostila T
Br Med J. 1977 Jan 8;1(6053):74-6. doi: 10.1136/bmj.1.6053.74.
Warts were found in 25 out of 56 patients with definite or probable systemic lupus erythematosus (SLE) but in only 19 out of 160 control patients. Warts were particularly prevalent in elderly patients with SLE. The corticosteroid and antimalarial drugs used to treat SLE did not influence the frequency of warts. Wart-virus antibodies were found significantly less often in patients with SLE than in controls: antibodies were detected in 23 out of 51 patients and in 40 out of 54 controls. Ihe findings suggest that some deficiency in the immune mechanisms of patients with SLE predisposes them to develop warts. There was an inverse correlation among the patients with SLE between the occurrence of warts and rheumatoid factor activity. This suggests that rheumatoid factor may interfere with resistance to warts.
在56例确诊或可能患有系统性红斑狼疮（SLE）的患者中，有25例发现患有疣，而在160例对照患者中仅有19例发现患有疣。疣在老年SLE患者中尤为普遍。用于治疗SLE的皮质类固醇和抗疟药物并不影响疣的发生率。SLE患者中发现疣病毒抗体的频率明显低于对照组：51例患者中有23例检测到抗体，54例对照组中有40例检测到抗体。这些发现表明，SLE患者免疫机制的某些缺陷使他们易患疣。在SLE患者中，疣的发生与类风湿因子活性之间存在负相关。这表明类风湿因子可能会干扰对疣的抵抗力。
