Morley D B
Department of Chemical Engineering, McGill University, Montreal, Canada.
Int J Artif Organs. 1991 Jun;14(6):371-9.
A coating technique employing a vibrated fluidized bed was used to apply an ultrathin (2 microns) cellulose nitrate coating to synthetic bead activated charcoal. In vitro characteristics of the resulting coated sorbent, including permeability to model small and middle molecules, and mechanical integrity, were evaluated to determine the suitability of the process in coating granular sorbents used in hemoperfusion. Initial tests suggest the VFB-applied CN coating is both highly uniform and tightly adherent and warrants further investigation as a hemosorbent coating.
采用振动流化床的包衣技术，将超薄（2微米）硝酸纤维素涂层涂覆在合成珠状活性炭上。对所得包衣吸附剂的体外特性进行评估，包括对模型小分子和中分子的渗透性以及机械完整性，以确定该工艺在涂覆用于血液灌流的颗粒吸附剂方面的适用性。初步测试表明，通过振动流化床涂覆的硝酸纤维素涂层高度均匀且附着力强，作为血液吸附剂涂层值得进一步研究。
