Cooney D O, Kane R P
Artif Organs. 1982 May;6(2):151-62. doi: 10.1111/j.1525-1594.1982.tb04077.x.
A novel hemoperfusion device was developed by embedding powered activated charcoal in thin (150 micrometer) films of cellulose nitrate. These films were sprinkled with small particles of granular charcoal and wound into spools, which were then placed in a plastic housing. The use of powdered charcoal exploits the enormous rate-of-uptake advantage of powered charcoal over the granular sorbents found in other hemoperfusion devices. The granular carbon sprinkled on the films was primarily to provide spacing between adjacent film layers for adequate fluid flow; the granules did enhance long-term uptake in addition. Clearance tests with this novel "thin-film adsorber," using sodium salicylate, sodium barbital, and creatinine, showed that its rate of solute adsorption, particularly at early times, was consistently very high. This type of hemoperfusion device is a promising alternative to the granular-sorbent types of devices currently available, especially when maximal solute removal during the early stages of treatment is mandated.
通过将动力活性炭嵌入硝酸纤维素薄（150微米）膜中，研发出了一种新型血液灌流装置。这些薄膜上撒有颗粒状活性炭的小颗粒，然后缠绕成线轴，再将线轴放置在塑料外壳中。使用粉末状活性炭利用了其相对于其他血液灌流装置中颗粒状吸附剂的巨大摄取速率优势。撒在薄膜上的颗粒状碳主要是为相邻薄膜层之间提供间距，以实现充分的流体流动；这些颗粒还增强了长期摄取。使用水杨酸钠、巴比妥钠和肌酐对这种新型“薄膜吸附器”进行的清除试验表明，其溶质吸附速率，尤其是在早期，一直非常高。这种类型的血液灌流装置是目前可用的颗粒状吸附剂类型装置的一种有前景的替代方案，特别是在治疗早期阶段要求最大程度溶质清除的情况下。
