Salvi Fabio, Giorgi Raffaella, Grilli Annalisa, Morichi Valeria, Espinosa Emma, Spazzafumo Liana, Marinozzi Maria Laura, Dessì-Fulgheri Paolo
Department of Internal Medicine, University Politecnica delle Marche, Ancona, Italy.
Aging Clin Exp Res. 2008 Aug;20(4):322-8. doi: 10.1007/BF03324863.
Protein and/or energy malnutrition is common in hospitalized older patients and is associated with poor outcomes. Among recommended nutritional screening tools, contrasting data exist about the usefulness of the Mini Nutritional Assessment Short-Form (MNA-SF). We evaluated whether the MNA-SF, alone or integrated with serum albumin levels, is a reliable predictor of functional decline in older patients.
We studied 275 elderly patients (mean age 76.5, 60.7% males) admitted to an acute medical ward of a tertiary-care teaching hospital over a 12-month period. In this observational study, we evaluated nutritional status, with the MNA-SF alone or integrated with albumin. Data were collected at admission and related to laboratory and geriatric assessment features, and length of stay (LOS). Functional decline (defined as a loss >or=10% in terms of Barthel Index score at discharge compared with 2 weeks before admission) was considered as outcome.
The MNA-SF estimated 46% patients at risk of malnutrition. These subjects had worse clinical features (lower total cholesterol and albumin levels), longer LOS (13.3 vs 11.2 days, p=0.014) and considerable functional decline (OR 4.25, 95% CI 1.83-9.9, p=0.001). Integrating the MNA-SF with albumin values, we obtained an effective instrument to detect older inpatients with protein-energy malnutrition, at higher risk of undergoing functional decline (OR 16.19, 95% CI 4.68-56.03, p<0.0001).
The MNA-SF is a useful screening tool for hospitalized elders at risk of malnutrition. It is associated with poor clinical outcomes and is able to predict functional decline. Together with hypoalbuminemia, it better identifies patients with true protein-energy malnutrition.
蛋白质和/或能量营养不良在住院老年患者中很常见,且与不良预后相关。在推荐的营养筛查工具中,关于简易营养评估简表(MNA-SF)的效用存在相互矛盾的数据。我们评估了MNA-SF单独使用或与血清白蛋白水平相结合是否是老年患者功能衰退的可靠预测指标。
我们研究了一家三级护理教学医院急性内科病房在12个月期间收治的275例老年患者(平均年龄76.5岁,男性占60.7%)。在这项观察性研究中,我们单独使用MNA-SF或结合白蛋白评估营养状况。在入院时收集数据,并与实验室检查、老年评估特征以及住院时间(LOS)相关联。功能衰退(定义为出院时Barthel指数评分较入院前2周下降≥10%)被视为研究结果。
MNA-SF评估出46%的患者存在营养不良风险。这些患者具有更差的临床特征(总胆固醇和白蛋白水平更低)、更长的住院时间(13.3天对11.2天,p = 0.014)以及明显的功能衰退(比值比4.25,95%置信区间1.83 - 9.9,p = 0.001)。将MNA-SF与白蛋白值相结合,我们得到了一种有效的工具,用于检测存在蛋白质 - 能量营养不良且功能衰退风险更高的老年住院患者(比值比16.19,95%置信区间4.68 - 56.03,p < 0.0001)。
MNA-SF是用于筛查有营养不良风险的住院老年人的有用工具。它与不良临床结局相关,并且能够预测功能衰退。与低白蛋白血症一起,它能更好地识别真正存在蛋白质 - 能量营养不良的患者。