Fernandes José Eduardo Vasconcelos, Franco Maria Isete Fares, Suzuki Reinaldo Kenji, Tavares Nelson Mattos, Bromberg Sansom Henrique
Postgraduate Program for Surgical Gastroenterology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil.
Sao Paulo Med J. 2008 Jul;126(4):220-2. doi: 10.1590/s1516-31802008000400004.
Gallbladder cancer is usually diagnosed at a late stage and generally results in death. Discovery of predisposing factors for this neoplasia could prevent this outcome. In this study, we assess the presence of one of these factors: intestinal metaplasia in gallbladders with stones and inflammatory processes.
Cross-sectional study in Hospital do Servidor Público Estadual de São Paulo.
The first 80 gallbladders from patients who underwent elective cholecystectomy between April and August 2002, presenting stones and chronic inflammation, were studied. The patients were divided into groups according to their age: CC1, from 15 to 40 years; CC2, from 41 to 60 years; and CC3, from 61 to 85 years.
Twenty-one patients (26%) were male, while 59 (74%) were female. In the group CC1, intestinal metaplasia was present in 85.71% of the 21 patients studied; in CC2, in 79.41% of 34 patients; and in CC3, in 56.00% of 25 patients. These differences presented statistical significance (p = 0.04542).
Intestinal metaplasia is extremely frequent in gallbladders with inflammation and lithiasis, especially in younger patients.
胆囊癌通常在晚期才被诊断出来，一般会导致死亡。发现这种肿瘤的诱发因素可能会避免这种结果。在本研究中，我们评估其中一个因素的存在情况：伴有结石和炎症过程的胆囊中的肠化生。
在圣保罗州立公务员医院进行的横断面研究。
对2002年4月至8月间接受择期胆囊切除术、伴有结石和慢性炎症的患者的前80个胆囊进行研究。根据年龄将患者分为几组：CC1组，年龄在15至40岁之间；CC2组，年龄在41至60岁之间；CC3组，年龄在61至85岁之间。
21名患者（26%）为男性，59名患者（74%）为女性。在CC1组中，21名接受研究的患者中有85.71%存在肠化生；在CC2组中，34名患者中有79.41%存在肠化生；在CC3组中，25名患者中有56.00%存在肠化生。这些差异具有统计学意义（p = 0.04542）。
肠化生在伴有炎症和结石的胆囊中极为常见，尤其是在年轻患者中。
