成人舌下神经根神经节细胞的存在：潜在的临床意义。
The existence of hypoglossal root ganglion cells in adult humans: potential clinical implications.
作者信息
Tubbs R Shane, El-Zammar Diala, Rogers Mark E, Kelly David R, Lott Robert, Chua Gina D, Shoja Mohammadali M, Loukas Marios, Oakes W Jerry, Cohen-Gadol Aaron A
机构信息
Section of Pediatric Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Surg Radiol Anat. 2009 Mar;31(3):173-6. doi: 10.1007/s00276-008-0422-6. Epub 2008 Oct 14.
INTRODUCTION
Ganglion cells of the hypoglossal nerve (HN) have been confirmed in certain animals but have been thought not to be present in man. To investigate for the presence of these structures in adult humans and if present, to verify their functionality, the present study was performed.
MATERIALS AND METHODS
We harvested adult cadaveric HN and observed for ganglion cells. Histological and immunohistochemical analyses were performed on all specimens.
RESULTS
Ganglion cells were found in 33% of specimens. Using immunohistochemistry, we found that these ganglia were sympathetic in nature. Based on our findings, ganglion cells do exist in the human HN although they are located sporadically and are found inconstantly.
CONCLUSIONS
Such information may be valuable in elucidating other functions of the HN and may aid in the histological diagnosis of this nerve. Additionally, pathology involving HN such as paragangliomas, are supported by our findings of the presence of autonomic ganglion cells in some HN specimens.
引言
舌下神经（HN）的神经节细胞在某些动物中已得到证实，但一直被认为在人类中不存在。为了研究这些结构在成年人类中的存在情况，以及如果存在的话，验证它们的功能，我们进行了本研究。
材料与方法
我们采集了成年尸体的舌下神经并观察神经节细胞。对所有标本进行了组织学和免疫组织化学分析。
结果
在33%的标本中发现了神经节细胞。通过免疫组织化学，我们发现这些神经节本质上是交感神经节。基于我们的发现，人类舌下神经中确实存在神经节细胞，尽管它们分布零散且不恒定。
结论
这些信息对于阐明舌下神经的其他功能可能有价值，并且可能有助于该神经的组织学诊断。此外，我们在一些舌下神经标本中发现自主神经节细胞的结果，为涉及舌下神经的病理学（如副神经节瘤）提供了支持。
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