Roman-Blas Jorge A, Jimenez Sergio A
Thomas Jefferson University, Jefferson Institute of Molecular Medicine, Philadelphia, Pennsylvania 19107, USA.
Int Rev Immunol. 2008;27(5):351-74. doi: 10.1080/08830180802295740.
The nuclear factor-kappa B family of transcription factors is intimately involved in the regulation of the inflammatory responses that play a fundamental role in the damage of articular tissues. Thus, many studies have examined the important contributions of components of the NF-kappaB signaling pathways to the pathogenesis of various rheumatic diseases and their pharmacologic modulation. Currently available therapeutic agents including nonsteroidal anti-inflammatory drugs, corticosteroids, nutraceuticals, and disease-modifying antirheumatic drugs, as well as novel specific small-molecule inhibitors have been employed. In addition, promising nucleic acid-based strategies have shown encouraging results. However, further research will be needed before NF-kappaB-aimed strategies become an effective therapy for inflammatory arthritis.
转录因子核因子-κB家族密切参与炎症反应的调节，而炎症反应在关节组织损伤中起重要作用。因此，许多研究探讨了NF-κB信号通路各组分对各种风湿性疾病发病机制及其药物调节的重要作用。目前已使用的治疗药物包括非甾体抗炎药、皮质类固醇、营养保健品、改善病情抗风湿药以及新型特异性小分子抑制剂。此外，基于核酸的有前景的策略已显示出令人鼓舞的结果。然而，在以NF-κB为靶点的策略成为炎症性关节炎的有效治疗方法之前，还需要进一步研究。
