Ayoglu H, Kulah C, Turan I
Departments of Anesthesiology and Reanimation, Karaelmas University School of Medicine, Zonguldak, Turkey.
Anaesth Intensive Care. 2008 Sep;36(5):681-4. doi: 10.1177/0310057X0803600508.
Some anaesthetic agents are known to inhibit microbial growth. The aim of this in vitro study was to investigate possible antimicrobial effects of two frequently used agents in intensive care units, dexmedetomidine and midazolam. Antimicrobial effect was tested on Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa by broth microdilution method. Midazolam showed inhibitor and bactericidal effect on S. aureus at concentrations 256 mmicrog x ml(-1) and 512/microg x ml(-1) respectively and on E. faecalis at concentrations 128 microg x ml(-1) and 256 microg x ml(-1). Dexmedetomidine demonstrated inhibitor effect on S. aureus, E. coli and P aeruginosa at concentrations 32 microg x ml(-1), 16 microg x ml(-1) and 16 microg x ml(-1) respectively. Midazolam had inhibitor and bactericidal effects on S. aureus and E. faecalis. Dexmedetomidine had only inhibitor effects on S. aureus, E. coli and P aeruginosa. Further studies are needed to determine the antimicrobial mechanisms and clinical applications.
已知某些麻醉剂可抑制微生物生长。本体外研究的目的是调查重症监护病房中两种常用药物右美托咪定和咪达唑仑可能的抗菌作用。采用肉汤微量稀释法对金黄色葡萄球菌、粪肠球菌、大肠杆菌和铜绿假单胞菌进行抗菌效果测试。咪达唑仑分别在浓度为256μg/ml和512μg/ml时对金黄色葡萄球菌显示出抑菌和杀菌作用，在浓度为128μg/ml和256μg/ml时对粪肠球菌显示出抑菌和杀菌作用。右美托咪定分别在浓度为32μg/ml、16μg/ml和16μg/ml时对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌显示出抑菌作用。咪达唑仑对金黄色葡萄球菌和粪肠球菌有抑菌和杀菌作用。右美托咪定仅对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌有抑菌作用。需要进一步研究以确定抗菌机制和临床应用。
