Philpott C M, Wild D C, Wolstensholme C R, Murty G E
Department of Otorhinolaryngology, Leicester Royal Infirmary, Leicester, United Kingdom.
Rhinology. 2008 Sep;46(3):221-5.
There is evidence in the literature showing a link between ovarian hormones and changes to nasal physiology.
The aim of this pilot study was to identify and quantify female hormone receptor positive cells in the nasal mucosa and to establish if there is a correlation with rhinitic symptoms.
Twenty-five adult patients attending a university hospital for routine, elective nonrhinological ENT procedures under general anaesthetic (mainly tonsillectomy) were recruited pre-operatively. Background information about each participant was recorded. Biopsies were taken from the inferior turbinates. These were analysed using immunohistochemistry techniques to assess for the presence of Progesterone, Oestrogen-alpha (ERalpha) and Oestrogen-beta (ERbeta) receptors. The mean number of cells positive for the receptors in each biopsy was deduced using a stratified random sampling technique.
All nasal biopsies were negative for progesterone and ERalpha receptors. ERbeta receptors were present in the mucosal glands in 24 out of the 25 biopsies. Using unpaired t-tests to compare the sexes, smoking status and atopic history no statistical difference was shown between any of these groups (p > 0.05). However, the rhinitis quality of life questionnaire score and the mean number of ERbeta receptor positive cells per biopsy showed a positive correlation (Pearson correlation of 0.4, p < 0.05).
The number of oestrogen receptor positive cells appears unaffected by sex, smoking history, hormone status, age or atopy. However, there is a significant positive relationship between the mean number of ERbeta positive cells and nasal symptoms. Pharmacological downregulation of ERbeta positive cells may reduce rhinitic symptoms and is the subject of further research.
文献中有证据表明卵巢激素与鼻腔生理变化之间存在联系。
本初步研究的目的是识别和量化鼻黏膜中女性激素受体阳性细胞，并确定其与鼻炎症状是否存在相关性。
术前招募了25名成年患者，他们因常规择期非鼻科耳鼻喉手术（主要是扁桃体切除术）在大学医院接受全身麻醉。记录了每位参与者的背景信息。从下鼻甲取活检组织。使用免疫组织化学技术对这些组织进行分析，以评估孕酮、雌激素α（ERα）和雌激素β（ERβ）受体的存在情况。使用分层随机抽样技术推断每次活检中受体阳性细胞的平均数量。
所有鼻活检组织中孕酮和ERα受体均为阴性。25份活检组织中有24份的黏膜腺中存在ERβ受体。使用未配对t检验比较性别、吸烟状况和特应性病史，这些组之间均未显示出统计学差异（p>0.05）。然而，鼻炎生活质量问卷评分与每次活检中ERβ受体阳性细胞的平均数量呈正相关（Pearson相关系数为0.4，p<0.05）。
雌激素受体阳性细胞的数量似乎不受性别、吸烟史、激素状态、年龄或特应性的影响。然而，ERβ阳性细胞的平均数量与鼻部症状之间存在显著正相关。ERβ阳性细胞的药理学下调可能会减轻鼻炎症状，这是进一步研究的主题。
