Kerkhof M H, Hendriks L, Brölmann H A M
Kennemer Gasthuis Haarlem, Haarlem, The Netherlands.
Int Urogynecol J Pelvic Floor Dysfunct. 2009 Apr;20(4):461-74. doi: 10.1007/s00192-008-0737-1. Epub 2008 Oct 15.
Little is known about the pathophysiology of pelvic organ prolapse (POP). In 1996, Jackson presented a hypothesis on pelvic floor connective tissue that tried to explain the development of POP on a molecular level. The objective of this review is to test the hypothesis against recent literature. The method used was a review of literature. The association between POP and connective tissue metabolism is well established. However, the causality of this association is unclear. The characteristics of the pelvic floor connective tissue of POP patients relate to tissue repair. To resolve the question of cause and effect, the role of fibroblasts in producing the extracellular matrix should be clarified. With these data, the use of autologous or allogenic stem cells in the treatment of POP may come in sight. Recent literature supports the hypothesis of Jackson but does not resolve long-standing questions on the aetiology of POP.
关于盆腔器官脱垂（POP）的病理生理学，人们了解甚少。1996年，杰克逊提出了一个关于盆底结缔组织的假说，试图在分子水平上解释POP的发展。本综述的目的是根据近期文献对该假说进行验证。所用方法为文献综述。POP与结缔组织代谢之间的关联已得到充分证实。然而，这种关联的因果关系尚不清楚。POP患者盆底结缔组织的特征与组织修复有关。为了解决因果问题，应阐明成纤维细胞在产生细胞外基质中的作用。有了这些数据，自体或异体干细胞在POP治疗中的应用可能指日可待。近期文献支持杰克逊的假说，但并未解决关于POP病因的长期问题。
