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1
Detection of Anaplasma marginale rickettsemia prior to onset of clinical signs by using an antigen capture enzyme-linked immunosorbent assay.通过使用抗原捕获酶联免疫吸附测定法在临床症状出现之前检测边缘无形体立克次体血症。
J Clin Microbiol. 1991 Jul;29(7):1542-4. doi: 10.1128/jcm.29.7.1542-1544.1991.
2
Development of enzyme-linked immunosorbent assays based on recombinant MSP1a and MSP2 of Anaplasma marginale.基于边缘无形体重组MSP1a和MSP2的酶联免疫吸附测定法的开发。
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Detection of cattle naturally infected with Anaplasma marginale in a region of endemicity by nested PCR and a competitive enzyme-linked immunosorbent assay using recombinant major surface protein 5.通过巢式聚合酶链反应和使用重组主要表面蛋白5的竞争性酶联免疫吸附测定法，在一个地方性流行区域检测自然感染边缘无形体的牛。
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Anaplasma marginale: detection of carrier cattle by PCR-ELISA.边缘无浆体：通过聚合酶链反应-酶联免疫吸附测定法检测携带病原体的牛
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本文引用的文献

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An evaluation of the complement-fixation test for anaplasmosis.无形体病补体结合试验的评估
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2
Pharmacotherapeutics of drugs used in treatment of anaplasmosis and babesiosis.用于治疗无形体病和巴贝斯虫病的药物的药物治疗学
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3
Common and isolate-restricted antigens of Anaplasma marginale detected with monoclonal antibodies.用单克隆抗体检测的边缘无形体的常见和菌株特异性抗原
Infect Immun. 1984 Sep;45(3):697-700. doi: 10.1128/iai.45.3.697-700.1984.
4
A rapid card agglutination test for bovine anaplasmosis.牛无浆体病快速卡片凝集试验
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Anaplasma marginale infection in young and aged cattle.幼龄和老龄牛的边缘无浆体感染
Am J Vet Res. 1968 Mar;29(3):535-44.
6
Immunization with an isolate-common surface protein protects cattle against anaplasmosis.用一种分离株共有的表面蛋白进行免疫接种可保护牛免受无形体病的侵害。
Science. 1986 Mar 14;231(4743):1299-302. doi: 10.1126/science.3945825.
7
Transmission of Anaplasma marginale Theiler by males of Dermacentor andersoni Stiles fed on an Idaho field-infected, chronic carrier cow.由取食爱达荷州野外感染的慢性带菌母牛的安德逊革蜱雄蜱传播边缘无形体（泰勒变种）。
Am J Vet Res. 1986 Oct;47(10):2269-71.
8
Detection of antibodies to Anaplasma marginale by an improved enzyme-linked immunosorbent assay with sodium dodecyl sulfate-disrupted antigen.用十二烷基硫酸钠裂解抗原改进的酶联免疫吸附试验检测边缘无形体抗体
J Clin Microbiol. 1987 Apr;25(4):633-6. doi: 10.1128/jcm.25.4.633-636.1987.
9
Detection and quantitation of Anaplasma marginale in carrier cattle by using a nucleic acid probe.利用核酸探针检测和定量带菌牛体内的边缘无浆体。
J Clin Microbiol. 1989 Feb;27(2):279-84. doi: 10.1128/jcm.27.2.279-284.1989.
10
Recognition of conserved surface protein epitopes on Anaplasma centrale and Anaplasma marginale isolates from Israel, Kenya and the United States.对来自以色列、肯尼亚和美国的中央无形体和边缘无形体分离株上保守表面蛋白表位的识别。
Int J Parasitol. 1988 Feb;18(1):33-8. doi: 10.1016/0020-7519(88)90033-1.

通过使用抗原捕获酶联免疫吸附测定法在临床症状出现之前检测边缘无形体立克次体血症。

Detection of Anaplasma marginale rickettsemia prior to onset of clinical signs by using an antigen capture enzyme-linked immunosorbent assay.

作者信息

Trueblood E S, McGuire T C, Palmer G H

机构信息

Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.

出版信息

J Clin Microbiol. 1991 Jul;29(7):1542-4. doi: 10.1128/jcm.29.7.1542-1544.1991.

DOI:10.1128/jcm.29.7.1542-1544.1991
PMID:1885753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC270153/
Abstract

An antigen capture enzyme-linked immunosorbent assay was developed by using monoclonal antibodies to conserved epitopes on the Anaplasma marginale MSP1a surface protein. The assay sensitivity was 1.1 (+/- 0.5)% parasitized erythrocytes, and all infected cattle were detected prior to development of 2.0%-parasitized erythrocytes. Positive tests preceded the onset of anemia by a mean of 2 days. The assay was specific for anaplasmosis, as demonstrated by nonreactivity with another common hemoparasitic pathogens.

摘要

利用针对边缘无形体MSP1a表面蛋白保守表位的单克隆抗体开发了一种抗原捕获酶联免疫吸附测定法。该测定法的灵敏度为1.1（±0.5）%的寄生红细胞，并且在寄生红细胞达到2.0%之前检测到了所有受感染的牛。阳性检测结果比贫血发作平均提前2天。该测定法对无形体病具有特异性，这通过与另一种常见血液寄生虫病原体无反应得到证明。