Lindahl K F
Howard Hughes Medical Institute, Department of Microbiology, University of Texas, Southwestern Medical Center, Dallas 75235-9050.
Trends Genet. 1991 Jul;7(7):219-24. doi: 10.1016/0168-9525(91)90368-z.
Histocompatibility antigens have been studied for over 50 years because they form a major obstacle to clinical transplantation. Human minor histocompatibility antigens remain ill-defined, but minor histocompatibility loci have been mapped on nearly every mouse chromosome. Recent molecular definition of several transplantation antigens suggests that they are by-products of an immune system poised to present viral antigens, and a mutation in any gene may give rise to a new minor histocompatibility antigen.
