内毒素给药后小鼠组胺敏感性增加。
Increased histamine sensitivity in mice after administration of endotoxins.
作者信息
Bergman R K, Munoz J J
出版信息
Infect Immun. 1977 Jan;15(1):72-7. doi: 10.1128/iai.15.1.72-77.1977.
Abstract
CFW mice given submicrogram doses of endotoxins intravenously became highly susceptible to the lethal effects of 0.5 mg of histamine given intraperitoneally 1 to 2 h later. The histamine-sensitizing effects of the endotoxins were transitory and disappeared within 6 to 8 h. L-Epinephrine administered intravenously immediately after histamine challenge protected mice from death, but aterenol and isoproterenol were ineffective. The histamine-sensitizing effect in endotoxins was precipitated by anti-endotoxin sera with a concomitant eightfold loss in activity. However, dissociation of the immune complex in 0.25 M acetic acid fully restored histamine-sensitizing activity. The transitory nature of the hypersensitivity produced by endotoxin and the high heat resistance of the active material prove that it is different from the histamine-sensitizing effects of pertussigen.
摘要
静脉注射亚微克剂量内毒素的CFW小鼠，在1至2小时后腹腔注射0.5毫克组胺时，对其致死作用变得高度敏感。内毒素的组胺致敏作用是短暂的，在6至8小时内消失。组胺激发后立即静脉注射L-肾上腺素可保护小鼠免于死亡，但去甲肾上腺素和异丙肾上腺素无效。抗内毒素血清可使内毒素中的组胺致敏作用沉淀，同时活性损失八倍。然而，在0.25 M乙酸中免疫复合物的解离可完全恢复组胺致敏活性。内毒素产生的超敏反应的短暂性质以及活性物质的高耐热性证明它与百日咳菌素的组胺致敏作用不同。
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