Norman J O, Elissalde M H
Infect Immun. 1979 May;24(2):427-33. doi: 10.1128/iai.24.2.427-433.1979.
Pregnant mice, guinea pigs, rats, and rabbits responded to injections of Moraxella bovis strain EPP-63(300) with abortion, death, embryo resorption, and production of small litters. The nature of response appeared to depend primarily on the number of viable cells injected and to some extent on the species of animal and stage of pregnancy. Intraperitoneal injection of mice with 3 X 10(5) viable cells induced 100% abortion and no deaths. Embryo resorption and smaller litters were induced with injection of lower doses of M. bovis. None of the rats used in this study aborted; however, resorption rates were higher in rats than mice. Bacteria-free filtrates prepared from aqueous extracts of blood agar on which M. bovis had been grown induced abortion in mice and guinea pigs, at a rate similar to that caused by viable cells. The lyophilized filtrate could be diluted to produce 100% abortion with no death of injected mice. Abortion-inducing, nonlethal doses of M. bovis and lyophilized filtrates appeared to have no effect on nonpregnant female or male mice.
怀孕的小鼠、豚鼠、大鼠和兔子对注射牛莫拉菌EPP - 63(300)菌株的反应包括流产、死亡、胚胎吸收和产仔数少。反应的性质似乎主要取决于注射的活细胞数量，在一定程度上还取决于动物的种类和怀孕阶段。给小鼠腹腔注射3×10⁵个活细胞可导致100%流产且无死亡。注射较低剂量的牛莫拉菌会导致胚胎吸收和产仔数减少。本研究中使用的大鼠均未流产；然而，大鼠的吸收发生率高于小鼠。从培养过牛莫拉菌的血琼脂水提取物中制备的无细菌滤液可诱导小鼠和豚鼠流产，其发生率与活细胞引起的相似。冻干滤液可稀释后导致100%流产，且注射的小鼠无死亡。诱导流产的非致死剂量的牛莫拉菌和冻干滤液似乎对未怀孕的雌性或雄性小鼠没有影响。
