Blancou J, Baltazar R S, Molli I, Stoltz J F
CNEVA, LERPAS, Malzéville, France.
Vaccine. 1991 Jun;9(6):432-7. doi: 10.1016/0264-410x(91)90131-o.
An experiment to assess the efficiency of the treatment recommended for humans after exposure to rabies was conducted in 68 sheep experimentally infected with a fox rabies virus. The infected sheep were divided into three groups and were given either a cell-culture vaccine (on the day of infection, then at day 3, 7, 14), human rabies immunoglobulin (26 IU kg-1 on the day of infection) or a combination of the vaccine immunoglobulin. The latter combination was the only treatment found to be effective in 100% of the animals, as 71% of the controls died. This model appears to be useful in assessing new regimens of postexposure treatment for humans as well as in the reconsideration of its feasibility, or validity, in animals.
一项在68只经实验感染狐狸狂犬病病毒的绵羊身上进行的实验，旨在评估针对人类暴露于狂犬病后推荐的治疗方法的有效性。受感染的绵羊被分成三组，分别给予细胞培养疫苗（感染当天，然后在第3、7、14天）、人狂犬病免疫球蛋白（感染当天26 IU/kg）或疫苗免疫球蛋白组合。后一种组合是唯一被发现对100%的动物有效的治疗方法，因为71%的对照组动物死亡。该模型似乎有助于评估人类暴露后治疗的新方案，以及重新考虑其在动物中的可行性或有效性。
