Weiling F
Am J Med Genet. 1991 Jul 1;40(1):1-25; discussion 26. doi: 10.1002/ajmg.1320400103.
The life and personality of Johann Gregor Mendel (1822-1884), the founder of scientific genetics, are reviewed against the contemporary background of his times. At the end are weighed the benefits for Mendel (as charged by Sir Ronald Fisher) to have documented his results on hand of falsified data. Mendel was born into a humble farm family in the "Kuhländchen", then a predominantly German area of Northern Moravia. On the basis of great gifts Mendel was able to begin higher studies; however, he found himself in serious financial difficulties because of his father's accident and incapacitation. His hardships engendered illness which threatened continuation and completion of his studies until he was afforded the chance of absolving successfully theological studies as an Augustinian monk in the famous chapter of St. Thomas in Altbrünn (Staré Brno). Psychosomatic indisposition made Mendel unfit for practical pastoral duties. Thus, he was directed to teach but without appropriate state certification; an attempt to pass such an examination failed. At that point he was sent to the University of Vienna for a 2-year course of studies, with emphasis on physics and botany, to prepare him for the exam. His scientific and methodologic training enabled him to plan studies of the laws of inheritance, which had begun to interest him already during his theology training, and to choose the appropriate experimental plant. In 1865, after 12 years of systematic investigations on peas, he presented his results in the famous paper "Versuche über Pflanzenhybriden." Three years after his return from Vienna he failed to attain his teaching certification a second time. Only by virtue of his exceptional qualifications did he continue to function as a Supplementary Professor of Physics and Natural History in the two lowest classes of a secondary school. In 1868 he was elected Abbot of his chapter, and freed from teaching duties, was able to pursue his many scientific interests with greater efficiency. This included meteorology, the measurement of ground water levels, further hybridization in plants (a.o. involving the hawk week Hieracium up to about 1873), vegetable and fruit tree horticulture, apiculture, and agriculture in general. This involved Mendel's active participation in many organizations interested in advancing these fields at a time when appropriate research institutes did not exist in Brünn. Some of the positions he took in his capacity of Abbot had severe repercussions and further taxed Mendel's already over-stressed system. The worst of these was a 10-year confrontation with the government about the taxation of the monastery.(ABSTRACT TRUNCATED AT 400 WORDS)
科学遗传学的奠基人约翰·格雷戈尔·孟德尔(1822 - 1884)的生平与性格,将在其所处时代的当代背景下进行审视。文末将权衡孟德尔(如罗纳德·费希尔爵士所指控的那样)因依据伪造数据记录结果而获得的好处。孟德尔出生于摩拉维亚北部一个以德语为主的地区“库赫兰琴”的一个贫苦农民家庭。凭借自身的天赋,孟德尔得以开始接受高等教育;然而,由于父亲的意外事故和丧失劳动能力,他陷入了严重的经济困境。他的艰难处境引发了疾病,这威胁到他学业的继续和完成,直到他有机会在阿尔特布吕恩(旧布尔诺)著名的圣托马斯修道院作为奥古斯丁修道士成功完成神学学业。身心不适使孟德尔不适合担任实际的牧师职责。于是,他被安排去教书,但没有获得相应的国家认证;一次参加此类考试的尝试失败了。在那时,他被派往维也纳大学进行为期两年的学习,重点是物理和植物学,为考试做准备。他所接受的科学和方法学训练使他能够规划对遗传规律的研究,而这在他进行神学训练时就已经开始引起他的兴趣,并且能够选择合适的实验植物。1865年,在对豌豆进行了12年的系统研究之后,他在著名的论文《植物杂交实验》中展示了他的研究成果。从维也纳回来三年后,他再次未能获得教学认证。只是凭借他卓越的资质,他才得以继续在一所中学的两个最低年级担任物理和自然历史的助理教授。1868年,他当选为修道院院长,从教学职责中解脱出来后,能够更高效地追求他众多的科学兴趣。这包括气象学、地下水位测量、植物的进一步杂交(例如直到1873年左右涉及鹰爪草属植物Hieracium)、蔬菜和果树园艺、养蜂以及一般农业。这意味着在布尔诺当时还没有合适的研究机构的时候,孟德尔积极参与了许多对推动这些领域发展感兴趣的组织。他以院长身份担任的一些职务产生了严重的影响,进一步加重了孟德尔本已不堪重负的身体状况。其中最糟糕的是与政府就修道院税收问题进行了长达十年的对峙。(摘要截取自400字)