Jones S E, Stokes M A
Department of Anaesthesia, Birmingham Children's Hospital, Ladywood Middleway, Birmingham.
Anaesthesia. 1991 Aug;46(8):688-90. doi: 10.1111/j.1365-2044.1991.tb09726.x.
The effectiveness of a continuous low dose papaveretum infusion for the relief of postoperative pain was assessed in 29 infants aged 1-6 months nursed on the infant surgical ward following major abdominal surgery. Trained nursing staff were able to adjust the dosage within prescribed guidelines and satisfactory analgesia was obtained with a regimen which delivered up to 0.0375 mg/kg/hour, approximately half the dose recommended in children older than 12 months. There was one case of clinically significant respiratory depression.
对29名1至6个月大、在婴儿外科病房接受重大腹部手术后护理的婴儿,评估了持续低剂量罂粟碱输注缓解术后疼痛的效果。训练有素的护理人员能够在规定指南范围内调整剂量,采用高达0.0375毫克/千克/小时的给药方案可获得满意的镇痛效果,这大约是12个月以上儿童推荐剂量的一半。有1例出现具有临床意义的呼吸抑制。