Sartori P C, Gordon G J, Darbyshire P J
Department of Haematology, Birmingham Children's Hospital.
Arch Dis Child. 1990 Oct;65(10):1151-3. doi: 10.1136/adc.65.10.1151.
We describe our experience of using continuous papaveretum infusions to control pain in 24 children admitted on 45 occasions with painful sickling crisis. The children were aged from 1.7 to 14.3 years. Infusion duration ranged from one to nine days (median three days), total dose from 0.3 to 21 mg/kg (median 2.4 mg/kg), with a pronounced tendency for dosage to increase with increasing age. No respiratory depression was observed. One infusion was discontinued because of cerebral toxicity.
我们描述了使用持续输注罂粟碱控制24名儿童镰状细胞危象疼痛的经验，这些儿童共入院45次。儿童年龄在1.7岁至14.3岁之间。输注持续时间为1至9天（中位数为3天），总剂量为0.3至21毫克/千克（中位数为2.4毫克/千克），且剂量有随年龄增长而明显增加的趋势。未观察到呼吸抑制现象。有一次输注因脑毒性而中断。
