Zhao L, Liu Z M, Piao Z Z
3rd Teaching Hospital, Norman Bethune University of Medical Sciences, Changchum.
Zhong Xi Yi Jie He Za Zhi. 1991 Jun;11(6):327-30, 323.
Antithrombotic xinmaining were composed with Moschus, Calculus Bovis, Borneol, Radix Ligusticum, Flos Sophorae Immaturus, Radix Salviae Miltiorrhizae, Leech, etc. This preparation was suitable for treating channels and collaterals type of cerebral thrombosis. The dosage was 2-4 capsules (0.5 g/capsule) oral administration twice per day, 3-4 weeks as a therapeutic course. The authors studied 158 cases of these patients compared with 117 cases of control group with dextran and Vinorutone. The clinical result showed that the obvious effective rate in the therapeutic group was 62.1% and the total effective rate 96.3%; the values in the control group were 38.5% and 86.3% respectively (P less than 0.01). The laboratory results showed that the blood viscosity, serum viscosity, hematocrit (vol %), RBC electrophoresis rate (micron/sec/v/cm) and platelet aggregation rate (%) before antithrombotic xinmaining administration were 5.82 +/- 0.82, 1.82 +/- 0.02, 52.81 +/- 6.70, 0.82 +/- 0.19 and 28.33 +/- 12.02 respectively; and those after the treatment were 4.72 +/- 0.65, 1.70 +/- 0.02, 48.76 +/- 0.40, 0.97 +/- 0.17 and 23.05 +/- 10.01 (mean +/- S), P less than 0.01. The toxicological study proved that the preparation was safe, no significant side-effect and good for cerebral thrombosis medication.
抗栓心脉宁由麝香、牛黄、冰片、川芎、槐米、丹参、水蛭等组成。该制剂适用于治疗脉络型脑血栓形成。剂量为2 - 4粒胶囊（0.5克/粒），口服，每日2次，3 - 4周为一个疗程。作者研究了158例此类患者，并与117例使用右旋糖酐和维脑路通的对照组患者进行比较。临床结果显示，治疗组的显效率为62.1%，总有效率为96.3%；对照组的值分别为38.5%和86.3%（P小于0.01）。实验室结果显示，服用抗栓心脉宁前血液粘度、血清粘度、红细胞压积（体积%）、红细胞电泳率（微米/秒/伏/厘米）和血小板聚集率（%）分别为5.82±0.82、1.82±0.02、52.81±6.70、0.82±0.19和28.33±12.02；治疗后分别为4.72±0.65、1.70±0.02、48.76±0.40、0.97±0.17和23.05±10.01（均值±标准差），P小于0.01。毒理学研究证明该制剂安全，无明显副作用，对脑血栓治疗有益。
