对工业有机溶剂二甲基甲酰胺暴露情况的无创监测。

A non-invasive monitoring of exposure to an industrial organic solvent, dimethylformamide.

作者信息

Chang M J, Lin R S

机构信息

Department of Public Health, Chang Gung Medical College, Taiwan.

出版信息

Drug Chem Toxicol. 1991;14(1-2):173-84. doi: 10.3109/01480549109017875.

DOI:10.3109/01480549109017875

PMID:1889375

Abstract

A urinary metabolite, N-hydroxymethyl-N-methyl formamide (DMF-OH) was measured by a colorimetric method in Wistar and Sprague-Dawley rat urine after a single exposure to N,N-dimethyl formamide (DMF). A linear relationship was found between the total excretion of DMF-OH in 2 days versus the exposure ranging from 1 to 20% of the LD50 of DMF i.e. 47.2 to 944 mg DMF per kg b. wt. This is proposed to be a non-invasive biological method for monitoring exposure to DMF.

摘要

采用比色法测定了Wistar大鼠和Sprague-Dawley大鼠单次接触N,N-二甲基甲酰胺（DMF）后尿液中的一种代谢产物N-羟甲基-N-甲基甲酰胺（DMF-OH）。结果发现，2天内DMF-OH的总排泄量与DMF半数致死量（LD50）的1%至20%（即每千克体重47.2至944毫克DMF）的暴露剂量之间呈线性关系。该方法被认为是一种监测DMF暴露的非侵入性生物学方法。