Ekdahl K N, Lööf L, Nyberg A, Nilsson U R, Nilsson B
Department of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala, Sweden.
Gastroenterology. 1991 Oct;101(4):1076-82. doi: 10.1016/0016-5085(91)90736-5.
Fc receptor-mediated clearance of immunoglobulin G-coated autologous erythrocytes was studied in patients with primary biliary cirrhosis (n = 14), alcoholic liver cirrhosis (n = 5) and healthy reference individuals (n = 14). The mean half-life of the sensitized erythrocytes was significantly prolonged in patients with primary biliary cirrhosis (85 +/- 25 minutes; P less than 0.001) compared with the corresponding value in patients with alcoholic cirrhosis (16 +/- 2 minutes) and healthy reference individuals (20 +/- 5 minutes), respectively. No correlation between clearance rate and age, liver histopathology, or serum levels of bilirubin, aminotransferases, immunoglobulin G, immunoglobulin A, and Clq binding or C3-containing immune complexes was found. The results presented here indicate a profound disturbance of Fc receptor-mediated immune clearance function in patients with primary biliary cirrhosis.
在原发性胆汁性肝硬化患者（n = 14）、酒精性肝硬化患者（n = 5）和健康对照个体（n = 14）中，研究了Fc受体介导的免疫球蛋白G包被的自体红细胞清除情况。与酒精性肝硬化患者（16±2分钟）和健康对照个体（20±5分钟）的相应值相比，原发性胆汁性肝硬化患者致敏红细胞的平均半衰期显著延长（85±25分钟；P<0.001）。未发现清除率与年龄、肝脏组织病理学或胆红素、氨基转移酶、免疫球蛋白G、免疫球蛋白A以及Clq结合或含C3免疫复合物的血清水平之间存在相关性。此处呈现的结果表明原发性胆汁性肝硬化患者Fc受体介导的免疫清除功能存在严重紊乱。
