Nilsson B, Nilsson U R, Karlsson-Parra A, Sjölin-Forsberg G, Hällgren R
Department of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala, Sweden.
Ann Rheum Dis. 1994 Oct;53(10):691-4. doi: 10.1136/ard.53.10.691.
To reconstitute a dysfunctional form of complement factor C3 in a patient with a systemic lupus erythematosus (SLE)-like syndrome.
The propositus was treated with plasma infusions during five sessions over a period of eight months.
The alternative pathway was reconstituted to normal levels for approximately two to three days after each infusion. C3 fragments were incorporated into previously detected deposits of IgG and IgM at the dermal-epidermal junction and the immune complex levels gradually decreased during the whole treatment period.
The reconstitution appears to result in the solubilisation of tissue immune complexes and a subsequent transportation to the fixed macrophage system.
在一名患有系统性红斑狼疮（SLE）样综合征的患者中重建功能失调的补体因子C3形式。
先证者在八个月的时间里分五次接受了血浆输注治疗。
每次输注后，替代途径在大约两到三天内恢复到正常水平。C3片段被整合到先前在真皮 - 表皮交界处检测到的IgG和IgM沉积物中，并且在整个治疗期间免疫复合物水平逐渐降低。
这种重建似乎导致组织免疫复合物溶解，并随后转运至固定巨噬细胞系统。
