Hettlich H J, Kaufmann R, Hunold W, Harmeyer H, Janssen B, Mittermayer C
Institut für Pathologie der Medizinischen Fakultät der RWTH, Aachen, Bundesrepublik Deutschland.
Fortschr Ophthalmol. 1991;88(3):274-8.
When oxygen plasma was used for plasma etching it was possible to hydrophilize the surface of silicone intraocular lenses (IOLs) without changing the chemical composition or the properties of deeper layers of the polymer. The modification was characterized by surface analysis. (Electron spectroscopy = XPS, contact angle estimations) and by scanning electron microscope. A cytotoxic influence of the modified surface could be excluded by cell culture experiments in which we evaluated cell spreading, cell morphology, DNA synthesis and protein synthesis. In vivo experiments on rabbits showed that the postoperative foreign body reaction was not significantly influenced by the hydrophilization of the IOL surface. Over the entire follow-up period (12 weeks), there was a reduced tendency to induce posterior synechiae in the group with hydrophilized lenses (P = 0.009). The number of dislocations and the incidence of posterior opacification did not differ significantly; on the other hand there were indications of improved adhesion to the posterior lens capsule of the hydrophilized IOL.
当使用氧等离子体进行等离子体蚀刻时，可以在不改变聚合物深层化学成分或性能的情况下使硅水凝胶人工晶状体（IOL）表面亲水化。通过表面分析（电子能谱 = XPS、接触角估计）和扫描电子显微镜对这种改性进行了表征。通过细胞培养实验可以排除改性表面的细胞毒性影响，在该实验中我们评估了细胞铺展、细胞形态、DNA合成和蛋白质合成。对兔子进行的体内实验表明，IOL表面的亲水化对术后异物反应没有显著影响。在整个随访期（12周）内，亲水化晶状体组诱发后粘连的趋势有所降低（P = 0.009）。脱位数量和后囊混浊发生率没有显著差异；另一方面，有迹象表明亲水化IOL与晶状体后囊的粘附性有所改善。
