Wenzel M, Kammann J, Allmers R
Augenklinik der RWTH Aachen.
Klin Monbl Augenheilkd. 1993 Dec;203(6):408-12. doi: 10.1055/s-2008-1045697.
In order to the biocompatibility of silicone intraocular lenses, which is described contradictory in literature, we compared IOLs made of silicone caoutchouc and PMMA-IOLs with regards to the presence of macrophages (i.e. giant cells or spindle-shaped cells) in a prospective, randomized study.
Totally 125 patients were examined 2 months post-operatively with the slitlamp in the refractive zone. The single-piece PMMA-IOLs with an open haptic used in this study had a 6 mm optical zone and a total diameter of 11 mm; the silicone-IOLs were disc-shaped lenses with a total diameter of 9.75 mm and an optical zone of 6 or 5.5 mm, resp.
Giant cells were observed with 16% of PMMA-lenses and 19% of the silicone-lenses. The maximal density of the giant cells on the PMMA-lenses at the median was 3/mm2 compared to 2/mm2 on the silicone IOLs. Small and spindle-shaped cells were found in 54% of the PMMA-IOLs and 46% of the silicone-lenses. The maximal cell density at the median was 10/mm2 with both lens types.
The differences between the two lens materials are statistically non-significant. Thus, silicone caoutchouc and PMMA possess a comparable biocompatibility when used as material for intraocular lenses.
为了研究文献中描述相互矛盾的硅酮人工晶状体的生物相容性，我们在一项前瞻性随机研究中，比较了由硅橡胶制成的人工晶状体和聚甲基丙烯酸甲酯人工晶状体中巨噬细胞（即巨细胞或梭形细胞）的存在情况。
总共125例患者在术后2个月使用裂隙灯在屈光区进行检查。本研究中使用的带有开放式襻的单片聚甲基丙烯酸甲酯人工晶状体的光学区为6mm，总直径为11mm；硅酮人工晶状体为盘状镜片，总直径为9.75mm，光学区分别为6mm或5.5mm。
在16%的聚甲基丙烯酸甲酯人工晶状体和19%的硅酮人工晶状体中观察到巨细胞。聚甲基丙烯酸甲酯人工晶状体上巨细胞的最大密度中位数为3个/mm²，而硅酮人工晶状体上为2个/mm²。在54%的聚甲基丙烯酸甲酯人工晶状体和46%的硅酮人工晶状体中发现了小的梭形细胞。两种晶状体类型的最大细胞密度中位数均为10个/mm²。
两种晶状体材料之间的差异在统计学上无显著意义。因此，硅橡胶和聚甲基丙烯酸甲酯作为人工晶状体材料时具有相当的生物相容性。
