爱泼斯坦-巴尔病毒早期抗原的D和R成分在再次感染后以及用5-碘脱氧尿苷诱导后的差异表达。
Differential expression of D and R components of Epstein-Barr virus early antigen after superinfection and after induction with 5-iododeoxyuridine.
作者信息
Simonová I, Závadová H, Vonka V
出版信息
Acta Virol. 1977 May;21(3):184-8.
Three non-productive human lymphoblastoid cell lines, NC-37, RAJI and L-1, either superinfected with Epstein-Barr (EB) virus from P3HR-1 cells or treated with 5-iododexyuridine (IUDR), were studied for the development of early antigen (EA) of EB virus. In all three superinfected cell lines, both the restricted (R) and diffuse (D) componets of EA were synthesized, with R-component formation preceding D-component synthesis. After IUDR treatment both components of EA were only formed in RAJI cells, while in NC37 and L-1 cells only the R-component was synthesized.
对三种无生产能力的人淋巴母细胞系NC-37、RAJI和L-1进行了研究，这些细胞系要么用来自P3HR-1细胞的爱泼斯坦-巴尔（EB）病毒进行超感染，要么用5-碘脱氧尿苷（IUDR）处理，以观察EB病毒早期抗原（EA）的产生情况。在所有三种超感染的细胞系中，EA的受限（R）成分和弥散（D）成分均有合成，R成分的形成先于D成分的合成。经IUDR处理后，EA的两种成分仅在RAJI细胞中形成，而在NC37和L-1细胞中仅合成了R成分。
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