Schnitzler L
Rev Fr Gynecol Obstet. 1991 Jun;86(6):469-73.
Collagen implants have extended our therapeutic possibilities: used either alone or as a complement to surgical methods, they are an answer to the demand of many patients (who are carefully selected on clinical and immunological criteria) for obvious short-term efficacy, the frequency of complementary injections to complete filling, depending on the location of the areas treated. The main reservation lies in the onset of phenomena of local delayed hypersensitivity, which appears to be reduced as far as possible by concomitant performance of the skin and serum tests for anti-collagen antibody. Human, placental collagen, which has not yet been marketed nor have the purified fluid silicones which are currently experiencing a revival of interest, may be the future hope for these often ignored allergies.
无论是单独使用还是作为手术方法的补充，它们都满足了许多患者（这些患者根据临床和免疫学标准经过精心挑选）对明显短期疗效的需求，根据治疗部位的不同，补充注射以完成填充的频率也有所不同。主要问题在于局部迟发性超敏反应现象的出现，通过同时进行皮肤和血清抗胶原蛋白抗体检测，这种现象似乎可以尽可能地减少。人胎盘胶原蛋白尚未上市，目前重新受到关注的纯化液态硅胶也是如此，它们可能是这些常被忽视的过敏症的未来希望所在。
