Knapp T R, Vistnes L M
Clin Plast Surg. 1985 Apr;12(2):221-5.
Clinical experience has demonstrated the value of injectable collagen in treating small soft-tissue defects. Among the lesions that respond best to injectable collagen therapy are nasolabial and glabellar lines as well as areas of atrophy and soft scars. This material is a useful adjunct to surgical procedures and can correct contour irregularities that may follow rhinoplasty or rhytidectomy. The safety of injectable collagen has also been well demonstrated. The nature and incidence of treatment reactions (less than 3 per cent) remains unchanged since the close of clinical trials. Reactions have been localized, and although some have been cosmetically undesirable, none has been health-threatening. All ultimately resolve without therapeutic intervention. Immunologic studies have confirmed the benign nature and specificity of reactions to injectable collagen. The importance of proper injection technique cannot be overstated. Immediately upon injection, tissue blanching followed by whealing and overcorrection should be evident. These indicate the desired superficial placement of the material. The overcorrection helps to compensate for the loss of carrier saline, and it quickly dissipates. When properly injected, injectable collagen can be used safely and effectively to correct an array of soft-tissue contour irregularities.
临床经验已证明可注射胶原蛋白在治疗小面积软组织缺损方面的价值。对可注射胶原蛋白治疗反应最佳的病变包括鼻唇沟和眉间纹，以及萎缩区域和软瘢痕。这种材料是手术的有用辅助手段，可纠正隆鼻术或除皱术后可能出现的轮廓不规则。可注射胶原蛋白的安全性也已得到充分证明。自临床试验结束以来，治疗反应的性质和发生率（低于3%）保持不变。反应是局部性的，虽然有些在美容上不理想，但没有一个对健康构成威胁。所有反应最终无需治疗干预即可消退。免疫学研究已证实对可注射胶原蛋白反应的良性性质和特异性。正确注射技术的重要性再怎么强调也不为过。注射后应立即出现组织变白，随后出现风团和过度矫正。这些表明材料所需的浅表放置位置。过度矫正有助于补偿载体盐水的流失，且会迅速消散。正确注射时，可注射胶原蛋白可安全有效地用于纠正一系列软组织轮廓不规则。
