Rossi M L, Jones N R, Esiri M M, Havas L, al Izzi M, Coakham H B
Dept of Neuropathology, Radcliffe Infirmary, Oxford, U.K.
Tumori. 1990 Dec 31;76(6):543-7. doi: 10.1177/030089169007600605.
Frozen sections from 28 pituitary adenomas were reached with a panel of monoclonal antibodies to macrophages, lymphocytes and HLA-Dr invariant chain. A low number of macrophages were demonstrated in all tumors, mainly perivascular. CD8 and CD4 lymphocytes were detected in even smaller numbers in 80% and 14% of tumors respectively. B lymphocytes were present in only 1 case. An occasional NK cell was present in 1/13 cases studied. HLA-Dr antigen was expressed by macrophages in all cases and by tumor cells in 2 growth hormone-producing adenomas/19 adenomas. These findings may represent evidence for a low degree of cellular immune response to pituitary adenomas.
用一组针对巨噬细胞、淋巴细胞和HLA - Dr恒定链的单克隆抗体对28例垂体腺瘤的冰冻切片进行检测。在所有肿瘤中均发现少量巨噬细胞，主要位于血管周围。分别在80%和14%的肿瘤中检测到数量更少的CD8和CD4淋巴细胞。仅在1例中发现B淋巴细胞。在所研究的13例中有1例偶尔出现自然杀伤细胞。在所有病例中巨噬细胞均表达HLA - Dr抗原，在19例腺瘤中有2例生长激素分泌型腺瘤的肿瘤细胞也表达该抗原。这些发现可能表明对垂体腺瘤存在低度的细胞免疫反应。
