Rossi M L, Jones N R, Esiri M M, Havas L, Nakamura N, Coakham H B
Department of Neuropathology, Radcliffe Infirmary, Oxford, UK.
Histol Histopathol. 1990 Oct;5(4):427-32.
Frozen sections from 37 schwannomas of the VIII nerve were reacted with a panel of monoclonal antibodies to macrophage, lymphocyte, HLA-Dr invariant chain and nuclear proliferation antigens. A moderate number of macrophages was demonstrated in 96% of tumours. CD8- and CD4-lymphocytes were detected in slightly smaller numbers in up to 87% and 23% of tumours respectively. B-lymphocytes were present in only 2/32 cases and NK-cells were absent from all 16 cases tested. HLA-Dr antigen was expressed by macrophages in most cases and by tumour cells in 13/24 tumours. These findings may represent evidence for a degree of cellular immune response. Occasional cells featuring nuclear proliferation were detected in 15/27 cases.
对37例第八脑神经施万瘤的冰冻切片，用一组针对巨噬细胞、淋巴细胞、HLA - Dr不变链和核增殖抗原的单克隆抗体进行反应。96%的肿瘤显示有中等数量的巨噬细胞。分别在高达87%和23%的肿瘤中检测到数量略少的CD8和CD4淋巴细胞。仅在2/32例中发现B淋巴细胞，在所有检测的16例中均未发现NK细胞。在大多数情况下，巨噬细胞表达HLA - Dr抗原，在13/24例肿瘤中肿瘤细胞也表达该抗原。这些发现可能代表了一定程度细胞免疫反应的证据。在15/27例中检测到偶尔有核增殖的细胞。
