用α-生育酚或辅酶Q10预处理的小鼠中阿霉素（多柔比星）的组织浓度。
Tissue concentration of doxorubicin (adriamycin) in mouse pretreated with alpha-tocopherol or coenzyme Q10.
作者信息
Shinozawa S, Gomita Y, Araki Y
机构信息
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
出版信息
Acta Med Okayama. 1991 Jun;45(3):195-9. doi: 10.18926/AMO/32205.
The tissue concentration of doxorubicin (adriamycin; ADM) and its major metabolite (aglycone I) was examined in mice pretreated with alpha-tocopherol (VE) or coenzyme Q10 (CoQ). In VE-pretreated group, the concentrations of aglycone I of the liver (1, 3 and 5 h after the administration), kidney (1 and 3h) and heart (3h) were significantly higher than those in the saline group. The clinical application of VE or CoQ concomitant with anti-tumor drugs especially ADM, requires caution.
在预先用α-生育酚（VE）或辅酶Q10（CoQ）处理的小鼠中检测了阿霉素（阿霉素；ADM）及其主要代谢产物（糖苷配基I）的组织浓度。在VE预处理组中，肝脏（给药后1、3和5小时）、肾脏（1和3小时）和心脏（3小时）的糖苷配基I浓度显著高于生理盐水组。VE或CoQ与抗肿瘤药物尤其是ADM同时进行临床应用时需要谨慎。
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